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Valvular Heart Disease and the Use of Dopamine Agonists for Parkinsons Disease
NEJM 356:39-46, Zanettini,R.,et al, 2007
See this aricle in Pubmed

Article Abstract
The frequency of clinically important valve regurgitation was significantly increased in patients taking pergolide or cabergoline, but not in patients taking non-ergot-derived dopamine agonists, as compared with control subjects. These findings should be considered in evaluating the risk-benefit ratio of treatment with ergot derivatives.
 
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adverse drug reaction
aortic valve,lesion of
cabergoline
dopamine agonist
echocardiogram
ergotamine
iatrogenic neurologic disorders
mitral valve lesion
mitral valve regurgitation
Parkinson disease
Parkinson disease,treatment of
pergolide
risk-benefit assessment
treatment of neurologic disorder
tricuspid valve,lesion of
valvulopathy

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